# Precision treatment in advanced hepatocellular carcinoma

*PRI Rank #1 · Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 197 |
| Journal | Cancer Cell |
| Year | 2024 |
| DOI | 10.1016/j.ccell.2024.01.007 |
| Corresponding authors | Jia Fan, Cun Wang, Qiang Gao |
| Institution | Fudan University, China |

**Ranking page:** [Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026](https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026)

**Paper link:** [10.1016/j.ccell.2024.01.007](https://doi.org/10.1016/j.ccell.2024.01.007)

## Topics

Hepatocellular carcinoma · Precision medicine · Advanced hepatocellular carcinoma · Targeted therapy · Biomarker · molecular subtypes · sorafenib · lenvatinib · Immune checkpoint inhibitor therapy · PD-1/PD-L1 inhibitor · Tumor microenvironment · Genomics · VEGF signaling pathway · mTOR pathway · TERT promoter mutation · TP53 mutation · CTNNB1 mutation · MET amplification · FGF19 amplification · Systemic therapy · Combination therapy · atezolizumab · bevacizumab · patient stratification · Predictive biomarker · tumor mutational burden · microsatellite instability · Hepatocellular carcinoma · next-generation sequencing · clinical outcomes

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026. https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```