# Semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomised trials

*PRI Rank #6 · Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 219 |
| Journal | The Lancet |
| Year | 2024 |
| DOI | 10.1016/s0140-6736(24)01643-x |
| Corresponding authors | Mikhail Kosiborod |
| Institution | Saint Luke's Mid America Heart Institute, United States |

**Ranking page:** [Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026](https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026)

**Paper link:** [10.1016/s0140-6736(24)01643-x](https://doi.org/10.1016/s0140-6736(24)01643-x)

## Topics

Semaglutide · Heart failure with preserved ejection fraction · Heart failure with mildly reduced ejection fraction · GLP-1 receptor agonist · Pooled analysis · Randomized controlled trial · SELECT trial · FLOW trial · STEP-HFpEF trial · STEP-HFpEF DM trial · Placebo · Cardiovascular events · Obesity · Type 2 diabetes · Chronic Kidney Disease · Left ventricular ejection fraction · weight loss · Heart failure hospitalization · Cardiovascular death · All-Cause Mortality · Kansas City Cardiomyopathy Questionnaire · Patient-reported outcomes · Composite Endpoint · Renal outcomes · Cardiometabolic disease · Body weight reduction · Heart failure symptoms · Diabetes management · Semaglutide cardioprotective effects · Secondary analysis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```