# Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction

*PRI Rank #16 · Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 63 |
| Journal | Circulation Research |
| Year | 2024 |
| DOI | 10.1161/circresaha.123.322381 |
| Corresponding authors | Yu-Chen Wang |
| Institution | University of California, Los Angeles, United States |

**Ranking page:** [Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026](https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026)

**Paper link:** [10.1161/circresaha.123.322381](https://doi.org/10.1161/circresaha.123.322381)

## Topics

Heart failure with preserved ejection fraction · Diastolic dysfunction · Indole-3-propionic acid · Gut microbiota dysbiosis · Tryptophan metabolism · Metabolomics · Nicotinamide N-methyltransferase · Nicotinamide N-methyltransferase · SIRT3 · Nicotinamide · NAD+/NADH ratio · Aryl hydrocarbon receptor · NAD+ salvage pathway · oxidative stress · Inflammation · Intestinal epithelial barrier dysfunction · Metabolic alterations · Obesity · Diabetes Mellitus · Mouse model of HFpEF · Dietary supplementation · Sirt3 knockdown · Nnmt knockdown · Nnmt overexpression · Gut-heart axis · Human HFpEF cohorts · Gut bacteria-derived metabolites · Cardiac energetics · Comorbidity-driven heart failure · Therapeutic microbiome modulation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```