# Inflammation in heart failure: pathophysiology and therapeutic strategies

*PRI Rank #15 · Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 63 |
| Journal | Inflammation Research |
| Year | 2024 |
| DOI | 10.1007/s00011-023-01845-6 |
| Corresponding authors | Michel White |
| Institution | Montreal Heart Institute, Canada |

**Ranking page:** [Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026](https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026)

**Paper link:** [10.1007/s00011-023-01845-6](https://doi.org/10.1007/s00011-023-01845-6)

## Topics

Heart failure · Inflammation · cytokines · chemokines · innate immune system · adaptive immune system · Heart failure with preserved ejection fraction · Heart failure with reduced ejection fraction · Ejection fraction classification · Inflammatory biomarkers · pro-inflammatory pathways · Acute decompensated heart failure · chronic heart failure · Guideline-Directed Medical Therapy · anti-inflammatory therapy · TNF-alpha · interleukin-6 · C-reactive protein · NLRP3 inflammasome · Cardiac remodeling · Myocardial fibrosis · immune-mediated cardiac injury · HF syndrome phenotypes · novel biomarkers · therapeutic trials targeting cytokines · pathophysiology of heart failure · targeted immunomodulatory therapy · Inflammation · Disease phenotyping · future therapeutic pipeline

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```