# Inflammation in Obesity-Related HFpEF

*PRI Rank #14 · Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 64 |
| Journal | Journal of the American College of Cardiology |
| Year | 2024 |
| DOI | 10.1016/j.jacc.2024.08.028 |
| Corresponding authors | Mikhail Kosiborod |
| Institution | University of Toronto, Canada |

**Ranking page:** [Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026](https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026)

**Paper link:** [10.1016/j.jacc.2024.08.028](https://doi.org/10.1016/j.jacc.2024.08.028)

## Topics

Obesity-related HFpEF · Inflammation · C-reactive protein · Semaglutide · GLP-1 receptor agonist · Body weight reduction · STEP-HFpEF trial · STEP-HFpEF trial · STEP-HFpEF DM trial · Randomized controlled trial · Placebo-controlled trial · KCCQ Clinical Summary Score · 6-minute walk distance · Hierarchical composite endpoint · Worsening heart failure events · health status · Functional impairment · exercise function · Body mass index · Biomarker stratification · Pooled analysis · Weight loss and inflammation relationship · baseline characteristics · Type 2 diabetes · Obesity · Cardiometabolic disease · Treatment effect heterogeneity · P interaction analysis · Clinical trial endpoints · Anti-inflammatory effect of semaglutide

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```