# Effects of Semaglutide on Heart Failure Outcomes in Diabetes and Chronic Kidney Disease in the FLOW Trial

*PRI Rank #12 · Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 86 |
| Journal | Journal of the American College of Cardiology |
| Year | 2024 |
| DOI | 10.1016/j.jacc.2024.08.004 |
| Corresponding authors | Richard E. Pratley |
| Institution | AdventHealth Translational Research Institute, United States |

**Ranking page:** [Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026](https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026)

**Paper link:** [10.1016/j.jacc.2024.08.004](https://doi.org/10.1016/j.jacc.2024.08.004)

## Topics

Semaglutide · Type 2 diabetes · Chronic Kidney Disease · Heart failure · Cardiovascular death · GLP-1 receptor agonist · FLOW trial · Renal dysfunction · Kidney replacement therapy · Renal composite endpoint · Randomized controlled trial · Placebo-controlled trial · Once-weekly dosing · Heart failure hospitalization · Urgent heart failure visit · Diuretic Therapy · Vasoactive therapy · New York Heart Association functional class · Heart failure with reduced ejection fraction · Time-to-event analysis · Hazard ratio · Secondary analysis · Cardiovascular risk reduction · Adjudication committee · Renal dysfunction · Diabetic kidney disease · Composite Endpoint · High-risk cardiometabolic population · Renal outcomes · GLP-1 receptor agonist cardioprotection

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```