# Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial

*PRI Rank #10 · Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 108 |
| Journal | Nature Medicine |
| Year | 2024 |
| DOI | 10.1038/s41591-024-03374-z |
| Corresponding authors | Barry A. Borlaug |
| Institution | Mayo Clinic, United States |

**Ranking page:** [Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026](https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026)

**Paper link:** [10.1038/s41591-024-03374-z](https://doi.org/10.1038/s41591-024-03374-z)

## Topics

tirzepatide · Heart failure with preserved ejection fraction · Heart failure with preserved ejection fraction · Obesity · Glucose-dependent insulinotropic polypeptide receptor · Glucose-dependent insulinotropic polypeptide receptor · GLP-1 receptor agonist · GLP-1 receptor agonist · circulatory volume expansion · pressure overload · cardiovascular-kidney end-organ damage · systolic blood pressure · estimated blood volume · C-reactive protein · Inflammation · Renal function · Urine albumin-creatinine ratio · microalbuminuria · Natriuretic peptides · Natriuretic peptides · troponin T · Cardiovascular death · Acute decompensated heart failure · KCCQ Clinical Summary Score · 6-minute walk distance · Renal function · myocardial injury · SUMMIT trial · Randomized controlled trial

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```