# Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity

*PRI Rank #1 · Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 726 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2410027 |
| Corresponding authors | Milton Packer |
| Institution | Baylor University Medical Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026](https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026)

**Paper link:** [10.1056/nejmoa2410027](https://doi.org/10.1056/nejmoa2410027)

## Topics

Heart failure with preserved ejection fraction · Obesity · tirzepatide · glucose-dependent insulinotropic polypeptide receptor agonist · GLP-1 receptor agonist · Cardiovascular events · weight loss · Body mass index · Cardiovascular death · Worsening heart failure events · Kansas City Cardiomyopathy Questionnaire · Patient-reported outcomes · Placebo-controlled trial · Left ventricular ejection fraction · Subcutaneous administration · Time-to-event analysis · Hazard ratio · gastrointestinal adverse events · Clinically meaningful improvement · dual incretin receptor agonist

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Heart Failure Treatment and Management Papers, Class of 2026. https://pri.pepkio.com/top-papers/heart-failure-treatment-and-management/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```