# Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria

*PRI Rank #8 · Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 135 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.03.014 |
| Corresponding authors | Chenhao Li |
| Institution | Broad Institute of MIT and Harvard, United States |

**Ranking page:** [Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026](https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026)

**Paper link:** [10.1016/j.cell.2024.03.014](https://doi.org/10.1016/j.cell.2024.03.014)

## Topics

Gut microbiome · Metabolomic profiling · Framingham Heart Study · cholesterol-metabolizing bacteria · cholesterol metabolism · microbial metabolism · Gut microbiome · serum metabolites · microbial enzymes · bile acids · coprostanol · cardiovascular disease · Metagenomic sequencing · metabolomics · Host-microbe interactions

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026. https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```