# Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer

*PRI Rank #6 · Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 162 |
| Journal | Cancer Cell |
| Year | 2024 |
| DOI | 10.1016/j.ccell.2024.08.019 |
| Corresponding authors | Jun Yu |
| Institution | The First Affiliated Hospital, China |

**Ranking page:** [Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026](https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026)

**Paper link:** [10.1016/j.ccell.2024.08.019](https://doi.org/10.1016/j.ccell.2024.08.019)

## Topics

Fusobacterium nucleatum · microsatellite stable colorectal cancer · Immune checkpoint blockade · Fecal microbiota transplantation · Butyrate · histone deacetylase 3/8 · CD8+ T cells · Tbx21 promoter · H3K27 acetylation · TBX21 · PD-1 transcriptional repression · CD8+ T cell exhaustion · CD34+-humanized mice · butyric acid-producing gene knockout · Tumor microbiome · Immunotherapy resistance · immunotherapy biomarker

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026. https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```