# Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer

*PRI Rank #3 · Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 187 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.02.022 |
| Corresponding authors | Shujie Chen, Liangjing Wang |
| Institution | Second Affiliated Hospital of Zhejiang University School of Medicine, China |

**Ranking page:** [Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026](https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026)

**Paper link:** [10.1016/j.cell.2024.02.022](https://doi.org/10.1016/j.cell.2024.02.022)

## Topics

Microbial metabolites · Immunotherapy response · T cell stemness · Pan-cancer analysis · Tumor microbiome · Immune checkpoint blockade · T cell stemness · metabolite-immune axis · CD8+ T cells · T cell exhaustion · antitumor immunity · Microbial metabolites · T cell differentiation · Immune modulation · Cancer immunotherapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026. https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```