# Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice

*PRI Rank #14 · Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 121 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.01.004 |
| Corresponding authors | Joseph J.�Y. Sung, Jun Yu |
| Institution | The Chinese University of Hong Kong, China |

**Ranking page:** [Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026](https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026)

**Paper link:** [10.1016/j.cell.2024.01.004](https://doi.org/10.1016/j.cell.2024.01.004)

## Topics

Streptococcus anginosus · gastric cancer · chronic gastritis · parietal cell atrophy · mucinous metaplasia · dysplasia · Gnotobiotic mice · YTN16 GC cell allografts · gastric barrier function · TMPC surface protein · Annexin A2 · ANXA2 receptor · gastric epithelial cells · MAPK activation · ANXA2 knockout · TMPC-ANXA2-MAPK axis · bacterial colonization · carcinogen-induced gastric tumorigenesis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026. https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```