# Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions

*PRI Rank #10 · Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 128 |
| Journal | Immunity |
| Year | 2024 |
| DOI | 10.1016/j.immuni.2024.02.014 |
| Corresponding authors | Wen Pan, Shu Zhu |
| Institution | University of Science and Technology of China, China |

**Ranking page:** [Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026](https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026)

**Paper link:** [10.1016/j.immuni.2024.02.014](https://doi.org/10.1016/j.immuni.2024.02.014)

## Topics

bile acids · Gut microbiome · Colorectal cancer · CD8+ T cells · T cell effector functions · Bile acid metabolism · tumor immunity · Microbiome-cancer interactions · immunosuppression

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Gut microbiota and health Papers, Class of 2026. https://pri.pepkio.com/top-papers/gut-microbiota-and-health/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```