# Activation of the insulin receptor by insulin-like growth factor 2

*PRI Rank #9 · Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 16 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-46990-6 |
| Corresponding authors | Xiao‐chen Bai, Eunhee Choi |
| Institution | University of Texas Southwestern Medical Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026](https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026)

**Paper link:** [10.1038/s41467-024-46990-6](https://doi.org/10.1038/s41467-024-46990-6)

## Topics

insulin receptor · Insulin-like growth factor 2 · Insulin-like growth factor 2 · IR-B isoform · IR-A isoform · cryo-EM structures · asymmetric conformations · site-1 · site-2 · T-shaped symmetric conformation · α-CT · FnIII-2 domain · C-loop · IR isoforms · receptor activation mechanism · IGF2 binding affinity · IR signaling · receptor trafficking

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026. https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```