# Cancer-associated fibroblasts promote the progression and chemoresistance of HCC by inducing IGF-1

*PRI Rank #7 · Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 19 |
| Journal | Cellular Signalling |
| Year | 2024 |
| DOI | 10.1016/j.cellsig.2024.111378 |
| Corresponding authors | Hui Guo, Yu-Zhu Hou |
| Institution | The Second Affiliated Hospital of Xi'an Jiaotong University, China |

**Ranking page:** [Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026](https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026)

**Paper link:** [10.1016/j.cellsig.2024.111378](https://doi.org/10.1016/j.cellsig.2024.111378)

## Topics

cancer-associated fibroblasts · Hepatocellular carcinoma · Interleukin-6 · Insulin-like growth factor 1 · Insulin-like growth factor 1 receptor · NT157 · STAT3 phosphorylation · IRS-1 degradation · AKT signalling · ERK-dependent manner · sorafenib · chemoresistance · IL-6-IGF-1 axis · CAF-tumor cell crosstalk · autocrine signaling · IGF-1R inhibitors · ERK MAPK pathway · sorafenib resistance

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026. https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```