# IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer

*PRI Rank #5 · Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 20 |
| Journal | Cell Death and Disease |
| Year | 2024 |
| DOI | 10.1038/s41419-024-06843-y |
| Corresponding authors | Heng Zhang, Shaoqiang Wang |
| Institution | Weifang People's Hospital, China |

**Ranking page:** [Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026](https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026)

**Paper link:** [10.1038/s41419-024-06843-y](https://doi.org/10.1038/s41419-024-06843-y)

## Topics

Insulin-like growth factor binding protein 2 · ITGA5 · gefitinib resistance · STAT3 · CXCL1 · Non-small cell lung cancer · Non-small cell lung cancer · EGFR-sensitive mutations · acquired resistance · non-EGFR secondary mutations · bronchoalveolar lavage fluid · transcriptional activation · biomarker · STAT3/CXCL1 axis · IGFBP2/ITGA5 axis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026. https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```