# Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2

*PRI Rank #3 · Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 22 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-50190-7 |
| Corresponding authors | Eiji Shigetomi, Schuichi Koizumi |
| Institution | University of Yamanashi, Japan |

**Ranking page:** [Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026](https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026)

**Paper link:** [10.1038/s41467-024-50190-7](https://doi.org/10.1038/s41467-024-50190-7)

## Topics

P2Y1 receptor · P2Y1 receptor · reactive astrocytes · neuronal hyperexcitability · astrocytic Ca2+ signals · neuronal Ca2+ signals · Insulin-like growth factor binding protein 2 · Insulin-like growth factor binding protein 2 · astrocyte-specific overexpression · epilepsy model · stroke model · astrocyte-neuron interaction · excitatory signaling · genetic upregulation · astrocyte-driven neuronal excitation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026. https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```