# IGF1 drives Wnt-induced joint damage and is a potential therapeutic target for osteoarthritis

*PRI Rank #2 · Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 23 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-53604-8 |
| Corresponding authors | Silvia Monteagudo |
| Institution | KU Leuven, Belgium |

**Ranking page:** [Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026](https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026)

**Paper link:** [10.1038/s41467-024-53604-8](https://doi.org/10.1038/s41467-024-53604-8)

## Topics

osteoarthritis · Wnt signaling · Insulin-like growth factor 1 · Insulin-like growth factor 1 · articular chondrocytes · cartilage-specific Igf1 deficiency · β-catenin · TCF4 · IGF1 gene promoter · post-traumatic osteoarthritis · cartilage-specific deletion · IGF1 silencing · Wnt-induced joint damage · Wnt transcription factor · disease-modifying therapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026. https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```