# Insulin and IGF-1 have both overlapping and distinct effects on CD4+ T cell mitochondria, metabolism, and function

*PRI Rank #12 · Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 13 |
| Journal | Scientific Reports |
| Year | 2024 |
| DOI | 10.1038/s41598-024-54836-w |
| Corresponding authors | Nancie J. MacIver |
| Institution | Duke University, United States |

**Ranking page:** [Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026](https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026)

**Paper link:** [10.1038/s41598-024-54836-w](https://doi.org/10.1038/s41598-024-54836-w)

## Topics

insulin · Insulin-like growth factor 1 · CD4+ T cells · insulin receptor · Insulin-like growth factor 1 receptor · Th17 cells · IL-17 production · mitochondrial membrane potential · Mitochondrial reactive oxygen species · hybrid IR/IGF-1R · T cell activation · T cell metabolism · Th17 differentiation · cytoprotective effect · receptor signaling · metabolic hormones

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026. https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```