# Exercise-Induced Reduction of IGF1R Sumoylation Attenuates Neuroinflammation in APP/PS1 Transgenic Mice

*PRI Rank #1 · Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 31 |
| Journal | Journal of Advanced Research |
| Year | 2024 |
| DOI | 10.1016/j.jare.2024.03.025 |
| Corresponding authors | John H. Zhang, Danping Liu, Yuzhen Xu, Dongyan Wu, Shiyi Chen |
| Institution | Huashan Hospital, China |

**Ranking page:** [Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026](https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026)

**Paper link:** [10.1016/j.jare.2024.03.025](https://doi.org/10.1016/j.jare.2024.03.025)

## Topics

IGF1R sumoylation · APP/PS1 transgenic mice · neuroinflammation · moderate-intensity exercise · Insulin-like growth factor 1 receptor · SUMO1 · nuclear translocation · KPT-330 · RanBP2 · XPO1 · IL-1β · Interleukin-6 · TNF-α · Bcl-2 · BACE1 · mutant IGF1R · IGF1R/RanBP2/SUMO1 complex · neuronal apoptosis · cognitive function · hippocampal protein expression

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026. https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```