# Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026

*Canonical URL: https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026*

## What topics and trends defined most-cited Growth Hormone and Insulin-like Growth Factors research in the Class of 2026?

The Class of 2026 is driven by precision treatment in acromegaly and evolving research on Insulin-like growth factor 1 receptors. Notably, acromegaly and pituitary adenoma saw significant growth in focus compared to the previous cohort, while traditional broad approaches shifted toward targeted biochemical control and related metabolic mechanisms.

## At a glance

| Fact | Value |
| --- | --- |
| Field | Growth Hormone and Insulin-like Growth Factors |
| Cohort label | Class of 2026 (2024 publications) |
| Papers analyzed | 2,917 |
| Papers ranked | 20 |
| Top topics in ranked papers | acromegaly, biochemical control, Insulin-like growth factor 1 receptor |
| Publication window | Jan 1, 2024 – Dec 31, 2024 |
| Eligibility | Research articles; reviews excluded |
| Citation window | 18 months post-publication |
| 18m citation range | 11–31 |
| Data source | OpenAlex · Retrieved September 2026 |
| License | CC BY 4.0 |

## Rankings

| Rank | Title | Authors | Corresponding authors | Affiliation | Journal | 18m citations | DOI |
| ---: | --- | --- | --- | --- | --- | ---: | --- |
| 1 | Exercise-Induced Reduction of IGF1R Sumoylation Attenuates Neuroinflammation in APP/PS1 Transgenic Mice | Yisheng Chen, Xiaofeng Chen, Zhiwen Luo, Xueran Kang, Yunshen Ge, Renwen Wan, Qian Wang, Zhihua Han, Fangqi Li, Zhongcheng Fan, Yuchun Xie, Beijie Qi, Xintao Zhang, Zhenwei Yang, John H Zhang, Danping Liu, Yuzhen Xu, Dongyan Wu, Shiyi Chen | John H. Zhang, Danping Liu, Yuzhen Xu, Dongyan Wu, Shiyi Chen | Huashan Hospital, China | Journal of Advanced Research | 31 | 10.1016/j.jare.2024.03.025 |
| 2 | IGF1 drives Wnt-induced joint damage and is a potential therapeutic target for osteoarthritis | Ana Escribano-Núñez, Frederique M F Cornelis, Astrid De Roover, An Sermon, Frédéric Cailotto, Rik J Lories, Silvia Monteagudo | Silvia Monteagudo | KU Leuven, Belgium | Nature Communications | 23 | 10.1038/s41467-024-53604-8 |
| 3 | Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2 | Eiji Shigetomi, Hideaki Suzuki, Yukiho J Hirayama, Fumikazu Sano, Yuki Nagai, Kohei Yoshihara, Keisuke Koga, Toru Tateoka, Hideyuki Yoshioka, Youichi Shinozaki, Hiroyuki Kinouchi, Kenji F Tanaka, Haruhiko Bito, Makoto Tsuda, Schuichi Koizumi | Eiji Shigetomi, Schuichi Koizumi | University of Yamanashi, Japan | Nature Communications | 22 | 10.1038/s41467-024-50190-7 |
| 4 | Acromegaly Disease Control Maintained After Switching From Injected Somatostatin Receptor Ligands to Oral Paltusotine | Mônica R Gadelha, Alessandra Casagrande, Christian J Strasburger, Martin Bidlingmaier, Peter J Snyder, Mirtha A Guitelman, Cesar L Boguszewski, Michael Buchfelder, Ilan Shimon, Gerald Raverot, Miklós Tóth, Emese Mezősi, Mirjana Doknic, Xiaolin Fan, David Clemmons, Peter J Trainer, R Scott Struthers, Alan Krasner, Beverly M K Biller | Mônica R. Gadelha | Universidade Federal do Rio de Janeiro, Brazil | The Journal of Clinical Endocrinology & Metabolism | 21 | 10.1210/clinem/dgae385 |
| 5 | IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer | Hengxiao Lu, Jiangshan Ai, Yingying Zheng, Wolong Zhou, Liming Zhang, Jiebo Zhu, Heng Zhang, Shaoqiang Wang | Heng Zhang, Shaoqiang Wang | Weifang People's Hospital, China | Cell Death and Disease | 20 | 10.1038/s41419-024-06843-y |
| 6 | Octreotide Subcutaneous Depot for Acromegaly: A Randomized, Double-blind, Placebo-controlled Phase 3 Trial, ACROINNOVA 1 | Diego Ferone, Pamela Freda, Laurence Katznelson, Federico Gatto, Pinar Kadioğlu, Pietro Maffei, Jochen Seufert, Julie M Silverstein, Joanna L Spencer-Segal, Elena Isaeva, Alexander Dreval, Maria Harrie, Agneta Svedberg, Fredrik Tiberg | Fredrik Tiberg | IRCCS Ospedale Policlinico San Martino, Italy | The Journal of Clinical Endocrinology & Metabolism | 20 | 10.1210/clinem/dgae707 |
| 7 | Cancer-associated fibroblasts promote the progression and chemoresistance of HCC by inducing IGF-1 | Ke-Jia Lv, Si-Zhe Yu, Yu Wang, Shi-Rong Zhang, Wen-Yuan Li, Jia Hou, De-Li Tan, Hui Guo, Yu-Zhu Hou | Hui Guo, Yu-Zhu Hou | The Second Affiliated Hospital of Xi'an Jiaotong University, China | Cellular Signalling | 19 | 10.1016/j.cellsig.2024.111378 |
| 8 | Cardiometabolic Risk Assessment in a Cohort of Children and Adolescents Diagnosed with Hyperinsulinemia | Giorgio Sodero, Donato Rigante, Lucia Celeste Pane, Linda Sessa, Ludovica Quarta, Marcello Candelli, Clelia Cipolla | Giorgio Sodero | Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy | Diseases | 17 | 10.3390/diseases12060119 |
| 9 | Activation of the insulin receptor by insulin-like growth factor 2 | Weidong An, Catherine Hall, Jie Li, Albert Hung, Jiayi Wu, Junhee Park, Liwei Wang, Xiao‐chen Bai, Eunhee Choi | Xiao‐chen Bai, Eunhee Choi | University of Texas Southwestern Medical Center, United States | Nature Communications | 16 | 10.1038/s41467-024-46990-6 |
| 10 | Central and peripheral regulation of the GH/IGF-1 axis: GHRH and beyond | Fabio Bioletto, Emanuele Varaldo, Valentina Gasco, Mauro Maccario, Emanuela Arvat, Ezio Ghigo, Silvia Grottoli | Silvia Grottoli | University of Turin, Italy | Reviews in Endocrine and Metabolic Disorders | 16 | 10.1007/s11154-024-09933-6 |
| 11 | Targeting IGF2 to reprogram the tumor microenvironment for enhanced viro-immunotherapy | Min Hye Noh, Jin Muk Kang, Alexandra A Miller, Grace Nguyen, Minxin Huang, Ji Seon Shim, Alberto J Bueso-Perez, Sara A Murphy, Kimberly A Rivera-Caraballo, Yoshihiro Otani, Eunju Kim, Seung-Hee Yoo, Yuanqing Yan, Yeshavanth Banasavadi-Siddegowda, Hiroshi Nakashima, E Antonio Chiocca, Balveen Kaur, Zhongming Zhao, Tae Jin Lee, Ji Young Yoo | Tae Jin Lee, Ji Young Yoo | The University of Texas Health Science Center at Houston, United States | Neuro-Oncology | 15 | 10.1093/neuonc/noae105 |
| 12 | Insulin and IGF-1 have both overlapping and distinct effects on CD4+ T cell mitochondria, metabolism, and function | Kaitlin Kiernan, Yazan Alwarawrah, Amanda G Nichols, Keiko Danzaki, Nancie J MacIver | Nancie J. MacIver | Duke University, United States | Scientific Reports | 13 | 10.1038/s41598-024-54836-w |
| 13 | Differences Between GH- and PRL-Cosecreting and GH-Secreting Pituitary Adenomas: a Series of 604 Cases | Marta Araujo-Castro, Betina Biagetti, Edelmiro Menéndez Torre, Iría Novoa-Testa, Fernando Cordido, Eider Pascual Corrales, Víctor Rodríguez Berrocal, Fernando Guerrero-Pérez, Almudena Vicente, Juan Carlos Percovich, Rogelio García Centeno, Laura González, María Dolores Ollero García, Ana Irigaray Echarri, María Dolores Moure Rodríguez, Cristina Novo-Rodríguez, María Calatayud, Rocío Villar, Ignacio Bernabéu, Cristina Alvarez-Escola, Pamela Benítez Valderrama, Carmen Tenorio-Jimenéz, Pablo Abellán Galiana, Eva Venegas Moreno, Inmaculada González Molero, Pedro Iglesias, Concepción Blanco, Fernando Vidal-Ostos De Lara, Paz de Miguel, Elena López Mezquita, Felicia Hanzu, Iban Aldecoa, Cristina Lamas, Silvia Aznar, Anna Aulinas, Anna Calabrese, Paola Gracia, José María Recio-Córdova, Mariola Aviles, Diego Asensio-Wandosel, Miguel Sampedro, Ignacio Ruz-Caracuel, Rosa Camara, Miguel Paja, Carmen Fajardo-Montañana, Mónica Marazuela, Manel Puig-Domingo | Betina Biagetti | Hospital Universitario Ramón y Cajal, Spain | The Journal of Clinical Endocrinology & Metabolism | 12 | 10.1210/clinem/dgae126 |
| 14 | Changes in acromegaly comorbidities, treatment, and outcome over three decades: a nationwide cohort study | Christian Rosendal, Mai Christiansen Arlien-Søborg, Eigil Husted Nielsen, Marianne Skovsager Andersen, Claus Larsen Feltoft, Marianne Klose, Mikkel Andreassen, Niels Henrik Bruun, Jens Otto Lunde Jørgensen, Jakob Dal | Christian Rosendal | Aalborg University Hospital, Denmark | Frontiers in Endocrinology | 12 | 10.3389/fendo.2024.1380436 |
| 15 | Insulin‐like growth factor‐1 in cirrhosis is linked to hepatic dysfunction and fibrogenesis and predicts liver‐related mortality | Lukas Hartl, Michael Schwarz, Benedikt Simbrunner, Mathias Jachs, Peter Wolf, David Josef Maria Bauer, Bernhard Scheiner, Lorenz Balcar, Georg Semmler, Benedikt Silvester Hofer, Nina Dominik, Rodrig Marculescu, Michael Trauner, Mattias Mandorfer, Thomas Reiberger | Thomas Reiberger | Medical University of Vienna, Austria | Alimentary Pharmacology & Therapeutics | 12 | 10.1111/apt.18289 |
| 16 | Protective Activities of Growth Hormone-Releasing Hormone Antagonists against Toxin-Induced Endothelial Injury | Saikat Fakir, Nektarios Barabutis | Nektarios Barabutis | University of Louisiana Monroe, United States | Endocrines | 12 | 10.3390/endocrines5010008 |
| 17 | Anastrozole vs Letrozole to Augment Height in Pubertal Males With Idiopathic Short Stature: A 3-Year Randomized Trial | Walter Zegarra, Sayali Ranadive, Diane Toulan, E Kirk Neely | E. Kirk Neely | Stanford University, United States | Journal of the Endocrine Society | 12 | 10.1210/jendso/bvae141 |
| 18 | Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit | Robert C Baxter | Robert C. Baxter | University of Sydney, Australia | Nature Reviews Endocrinology | 11 | 10.1038/s41574-024-00970-4 |
| 19 | A spatiotemporal molecular atlas of mouse spinal cord injury identifies a distinct astrocyte subpopulation and therapeutic potential of IGFBP2 | Zeqing Wang, Zhuxia Li, Tianle Luan, Guizhong Cui, Shunpan Shu, Yiyao Liang, Kai Zhang, Jingshu Xiao, Wei Yu, Jihong Cui, Ang Li, Guangdun Peng, Yanshan Fang | Ang Li, Guangdun Peng, Yanshan Fang | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China | Developmental Cell | 11 | 10.1016/j.devcel.2024.06.016 |
| 20 | The changing landscape of acromegaly – an epidemiological perspective | Christian Rosendal, Mai Christiansen Arlien-Søborg, Eigil Husted Nielsen, Marianne Skovsager Andersen, Claus Larsen Feltoft, Caroline Kistorp, Olaf M Dekkers, Jens Otto Lunde Jørgensen, Jakob Dal | Christian Rosendal | Aalborg University Hospital, Denmark | Reviews in Endocrine and Metabolic Disorders | 11 | 10.1007/s11154-024-09875-z |

## Topic trends

### What Topics Define the Class of 2026?

The research landscape for the Class of 2026 is prominently shaped by investigations into targeted treatments and precise physiological mechanisms. Acromegaly, biochemical control, and the Insulin-like growth factor 1 receptor stand out as central themes, reflecting a strong clinical focus on effective management of related disorders. Furthermore, topics such as Pituitary adenoma and IGF-1 normalization highlight an ongoing drive to refine diagnosis and therapeutic outcomes. This strong concentration suggests the field is moving beyond basic discovery toward advanced, clinically applicable interventions that target underlying mechanisms of disease.

*Leading research themes*

### How Did Topics Shift from the Class of 2025 to the Class of 2026?

The shift from the Class of 2025 to the Class of 2026 reveals a notable pivot toward specialized clinical targets. Acromegaly and Pituitary adenoma experienced substantial growth, indicating an increased research priority on these conditions and their management. Concurrently, broader metabolic topics like Insulin-like growth factor 1 receptor biology maintained a steady presence but with growing context around precise biochemical control. These trends demonstrate a field increasingly prioritizing targeted therapeutic strategies and refined clinical outcomes over more generalized endocrinological studies.

*How topics shifted year over year*

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Growth Hormone and Insulin-like Growth Factors Papers, Class of 2026. https://pri.pepkio.com/top-papers/growth-hormone-and-insulin-like-growth-factors/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
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