# O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology

*PRI Rank #9 · Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 44 |
| Journal | Nature Chemical Biology |
| Year | 2024 |
| DOI | 10.1038/s41589-024-01551-2 |
| Corresponding authors | Hilal A. Lashuel, Matthew R. Pratt |
| Institution | University of Southern California, United States |

**Ranking page:** [Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026)

**Paper link:** [10.1038/s41589-024-01551-2](https://doi.org/10.1038/s41589-024-01551-2)

## Topics

O-GlcNAcylation · α-synuclein · amyloid strains · fibril structure · seeding activity · Parkinson's disease · cryogenic electron microscopy · seeding-based neuronal models · rodent models · heat shock proteins · post-translational modification · amyloid pathogenicity · fibril core structure · seeding neutralization · protein interactome

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```