# Sialylated glycoproteins suppress immune cell killing by binding to Siglec-7 and Siglec-9 in prostate cancer

*PRI Rank #19 · Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 36 |
| Journal | Journal of Clinical Investigation |
| Year | 2024 |
| DOI | 10.1172/jci180282 |
| Corresponding authors | Ru M Wen |
| Institution | Department of Urology, United States |

**Ranking page:** [Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026)

**Paper link:** [10.1172/jci180282](https://doi.org/10.1172/jci180282)

## Topics

Siglec-7 · Siglec-9 · sialylated glycoproteins · immune evasion · myeloid cells · macrophage · prostate tumor tissue · sialic acid · immune cell infiltration · humanized mice · CRISPRi screen · mass spectrometry · CD59 · Siglec-9 ligand · CD59/Siglec-9 axis · Immune checkpoint · prostate cancer xenograft

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```