# Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions

*PRI Rank #15 · Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 38 |
| Journal | Communications Biology |
| Year | 2024 |
| DOI | 10.1038/s42003-024-06087-8 |
| Corresponding authors | Yvette van Kooyk |
| Institution | Amsterdam UMC, Netherlands |

**Ranking page:** [Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026)

**Paper link:** [10.1038/s42003-024-06087-8](https://doi.org/10.1038/s42003-024-06087-8)

## Topics

pancreatic ductal adenocarcinoma · pancreatic ductal adenocarcinoma · cancer-associated fibroblasts · CAFs · sialic acid · Siglecs · Siglec-7 · Siglec-9 · Siglec-10 · Siglec-15 · ST3GAL4 · tumor microenvironment · myeloid cells · tumor-associated macrophages · monocyte differentiation · multiplex immunohistochemistry · Transcriptomics · sialylation · Immune checkpoint · CAF-mediated immunomodulation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```