# Designed endocytosis-inducing proteins degrade targets and amplify signals

*PRI Rank #1 · Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 105 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07948-2 |
| Corresponding authors | David Baker |
| Institution | University of Washington, United States |

**Ranking page:** [Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026](https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026)

**Paper link:** [10.1038/s41586-024-07948-2](https://doi.org/10.1038/s41586-024-07948-2)

## Topics

EndoTags · endocytosis-triggering binding proteins · computational protein design · lysosomal trafficking · targeted protein degradation · insulin-like growth factor 2 receptor (IGF2R) · asialoglycoprotein receptor (ASGPR) · sortilin receptor · transferrin receptor · PD-L1 antibody · AND gate control · engineered cell secretion · LYTACs · KineTACs · genetically encoded degraders · tissue-specific degradation · endocytosis-dependent signaling amplification · antibody-drug conjugates · transmembrane protein targeting · mouse tumor model

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Glycosylation and Glycoproteins Research Papers, Class of 2026. https://pri.pepkio.com/top-papers/glycosylation-and-glycoproteins-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```