# OrthoDB and BUSCO update: annotation of orthologs with wider sampling of genomes

*PRI Rank #8 · Topics and Trends in Most Cited Genomics and Phylogenetic Studies Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-phylogenetic-studies/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 213 |
| Journal | Nucleic Acids Research |
| Year | 2024 |
| DOI | 10.1093/nar/gkae987 |
| Corresponding authors | Fredrik Tegenfeldt |
| Institution | University of Geneva, Switzerland |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Phylogenetic Studies Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-phylogenetic-studies/2026)

**Paper link:** [10.1093/nar/gkae987](https://doi.org/10.1093/nar/gkae987)

## Topics

OrthoDB · BUSCO · Orthologous groups · hierarchical gene orthology · OrthoLoger · ODB-mapper · Single-copy orthologs · REST API · SPARQL/RDF · coding DNA sequences · gene loci coordinates · Functional annotation · evolutionary annotation · Genome assembly · metagenomic bins · transcriptomes · Conda package · BioContainers · Python API · R Bioconductor

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Phylogenetic Studies Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-phylogenetic-studies/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```