# KEGG: biological systems database as a model of the real world

*PRI Rank #1 · Topics and Trends in Most Cited Genomics and Phylogenetic Studies Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-phylogenetic-studies/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 1,911 |
| Journal | Nucleic Acids Research |
| Year | 2024 |
| DOI | 10.1093/nar/gkae909 |
| Corresponding authors | Minoru Kanehisa |
| Institution | Kyoto University, Japan |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Phylogenetic Studies Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-phylogenetic-studies/2026)

**Paper link:** [10.1093/nar/gkae909](https://doi.org/10.1093/nar/gkae909)

## Topics

KEGG · Pathway maps · KEGG Orthology (KO) · Pathway maps · metagenomes · Taxonomic assignment · Conserved gene orders · Virus ortholog group (VOG) · KO sequences · Virus ortholog group (VOG) · biological systems database · Molecular interaction networks · Molecular interaction networks · KO assigned genomes · conserved genes · virus proteins · cellular organisms · Pathway maps · multi-organism processes

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Phylogenetic Studies Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-phylogenetic-studies/2026. Accessed 2026-07-17.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```