# Genome organization around nuclear speckles drives mRNA splicing efficiency

*PRI Rank #7 · Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 98 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07429-6 |
| Corresponding authors | Mitchell Guttman |
| Institution | California Institute of Technology, United States |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026)

**Paper link:** [10.1038/s41586-024-07429-6](https://doi.org/10.1038/s41586-024-07429-6)

## Topics

nuclear speckles · mRNA splicing efficiency · 3D genome organization · 3D genome organization · splicing factor compartmentalization · chromatin-speckle interactions · nuclear bodies · co-transcriptional splicing · subnuclear localization · gene positioning · splicing kinetics · 3D genome organization · transcription-splicing coupling · Chromosome organization · chromatin domains

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```