# Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation

*PRI Rank #6 · Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 99 |
| Journal | Nature Reviews Molecular Cell Biology |
| Year | 2024 |
| DOI | 10.1038/s41580-024-00710-6 |
| Corresponding authors | Anders S. Hansen |
| Institution | Massachusetts Institute of Technology, United States |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026)

**Paper link:** [10.1038/s41580-024-00710-6](https://doi.org/10.1038/s41580-024-00710-6)

## Topics

Enhancer-promoter selectivity · Enhancer-promoter interactions · promoter activation · spatiotemporal regulation · transcriptional specificity · Chromatin loops · Cis-regulatory elements · Transcription factor binding · Enhancer-promoter interactions · cis-regulatory mechanisms

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```