# HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription

*PRI Rank #5 · Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 102 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-47900-6 |
| Corresponding authors | Chen Chen, Kai Zhang |
| Institution | Tianjin Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026)

**Paper link:** [10.1038/s41467-024-47900-6](https://doi.org/10.1038/s41467-024-47900-6)

## Topics

lysine lactylation · HBO1 · lysine lactyltransferase · histone H3K9la · E508 catalytic site · Quantitative proteomics · JADE1 · BRPF2 · scaffold proteins · CUT&Tag · transcription start sites · Transcriptional regulation · tumorigenesis · HBO1 knockout · Histone modifications · metabolic regulation of gene expression

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```