# TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation

*PRI Rank #4 · Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 105 |
| Journal | European Heart Journal |
| Year | 2024 |
| DOI | 10.1093/eurheartj/ehae379 |
| Corresponding authors | Shaoliang Chen, Yong Ji, Hongshan Chen |
| Institution | Nanjing Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026)

**Paper link:** [10.1093/eurheartj/ehae379](https://doi.org/10.1093/eurheartj/ehae379)

## Topics

TRAP1 · vascular smooth muscle cell senescence · atherosclerosis · Histone H4 lysine 12 lactylation · Histone H4 lysine 12 lactylation · HDAC3 · metabolic reprogramming · aerobic glycolysis · lactate production · Senescence-associated secretory phenotype · Senescence-associated secretory phenotype · mitonuclear communication · VSMC-specific knockout · ApoeKO mice · oncogenic Ras · PROTAC-mediated degradation · histone lysine delactylase · Chromatin immunoprecipitation · senescence-associated β-galactosidase · pharmacological inhibition

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```