# Sequence basis of transcription initiation in the human genome

*PRI Rank #20 · Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 55 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adj0116 |
| Corresponding authors | Donghong Cai, Chenlai Shi, Jian Zhou |
| Institution | University of Texas Southwestern Medical Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026)

**Paper link:** [10.1126/science.adj0116](https://doi.org/10.1126/science.adj0116)

## Topics

Transcription initiation · base-pair resolution prediction · Deep learning models · Puffin · explainable model · human promoters · sequence patterns · position-specific effects · bidirectional transcription · transcription start sites · gene expression variation · Cell type specificity · sequence determinants · mammalian species conservation · promoter activity · sequence rules

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```