# Position-dependent function of human sequence-specific transcription factors

*PRI Rank #19 · Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 56 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07662-z |
| Corresponding authors | Sascha H. Duttke, Sven Heinz, Christopher Benner |
| Institution | Washington State University, United States |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026)

**Paper link:** [10.1038/s41586-024-07662-z](https://doi.org/10.1038/s41586-024-07662-z)

## Topics

transcription start sites · sequence-specific transcription factors · position-dependent transcription factor function · promoters · enhancers · TF binding site positioning · NRF1 · NFY · Sp1 · Genetic variation · massively parallel reporter assays · Transcription initiation · TF spacing · activator-to-repressor switching · regulatory element architecture · non-coding DNA polymorphisms · motif positioning patterns · synthetic regulatory elements · TSS-relative binding site analysis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```