# Increased enhancer–promoter interactions during developmental enhancer activation in mammals

*PRI Rank #18 · Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 56 |
| Journal | Nature Genetics |
| Year | 2024 |
| DOI | 10.1038/s41588-024-01681-2 |
| Corresponding authors | Evgeny Z. Kvon |
| Institution | University of California, Irvine, United States |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026)

**Paper link:** [10.1038/s41588-024-01681-2](https://doi.org/10.1038/s41588-024-01681-2)

## Topics

Enhancer-promoter interactions · developmental enhancer activation · Chromatin loops · Gene expression regulation · Transcriptional regulation · Chromosome conformation capture · Hi-C · 4C-seq · developmental gene expression · Cis-regulatory elements · Chromatin structure · enhancer dynamics · promoter contacts · Transcription factors · mammalian development · Long-range interactions · chromatin contact frequency · Enhancer-promoter interactions

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```