# Single-cell nascent RNA sequencing unveils coordinated global transcription

*PRI Rank #14 · Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 64 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07517-7 |
| Corresponding authors | Phillip A. Sharp |
| Institution | Massachusetts Institute of Technology, United States |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026)

**Paper link:** [10.1038/s41586-024-07517-7](https://doi.org/10.1038/s41586-024-07517-7)

## Topics

scGRO-seq · single-cell nascent RNA sequencing · click chemistry · Transcriptional bursting · burst size · burst frequency · divergent transcription initiation · enhancer-gene coordination · Super-enhancers · unstable RNAs · co-transcription · RNA polymerase quantification · replication-dependent histone genes · non-polyadenylated histone gene transcription · Cell cycle dynamics · Enhancer networks · temporal transcription regulation · episodic transcription

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```