# Chromosomal instability as a driver of cancer progression

*PRI Rank #12 · Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 75 |
| Journal | Nature Reviews Genetics |
| Year | 2024 |
| DOI | 10.1038/s41576-024-00761-7 |
| Corresponding authors | Samuel F. Bakhoum |
| Institution | Memorial Sloan Kettering Cancer Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026)

**Paper link:** [10.1038/s41576-024-00761-7](https://doi.org/10.1038/s41576-024-00761-7)

## Topics

chromosomal instability · cancer progression · aneuploidy · structural chromosomal aberrations · Mitotic errors · centrosome amplification · kinetochore-microtubule attachments · spindle assembly checkpoint · DNA damage response · replication stress · chromothripsis · Micronuclei · copy number alterations · tumor heterogeneity · Metastasis · therapeutic resistance · Chromosomal missegregation · Genomic instability

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```