# Histone lactylation couples cellular metabolism with developmental gene regulatory networks

*PRI Rank #11 · Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 77 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-023-44121-1 |
| Corresponding authors | Marcos Simões-Costa |
| Institution | Cornell University, United States |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026)

**Paper link:** [10.1038/s41467-023-44121-1](https://doi.org/10.1038/s41467-023-44121-1)

## Topics

histone lactylation · glycolysis · gene regulatory networks · neural crest · pre-somitic mesoderm · Chromatin accessibility · active enhancers · LDHA/B · lactyl-CoA · SOX9 · YAP/TEAD · metabolic reprogramming · Embryonic development · cell migration · epigenetic mechanism · NC GRN deployment

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```