# DPF2 reads histone lactylation to drive transcription and tumorigenesis

*PRI Rank #10 · Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 81 |
| Journal | Proceedings of the National Academy of Sciences |
| Year | 2024 |
| DOI | 10.1073/pnas.2421496121 |
| Corresponding authors | Guijin Zhai, Ziping Niu, Zixin Jiang, Kai Zhang |
| Institution | Tianjin Medical University, China |

**Ranking page:** [Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026](https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026)

**Paper link:** [10.1073/pnas.2421496121](https://doi.org/10.1073/pnas.2421496121)

## Topics

lysine lactylation · Kla · histone lactylation · H3K14la · DPF2 · cervical cancer · lactate accumulation · metabolic reprogramming · multivalent photoaffinity probe · Quantitative proteomics · CUT&Tag · histone reader protein · oncogenic gene expression · DPF2-H3K14la interaction · structure-guided mutation · Transcriptional regulation · cell survival · histone mark effector

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genomics and Chromatin Dynamics Papers, Class of 2026. https://pri.pepkio.com/top-papers/genomics-and-chromatin-dynamics/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```