# Genomic structural variation contributes to evolved changes in gene expression in high-altitude Tibetan sheep

*PRI Rank #4 · Topics and Trends in Most Cited Genetic and phenotypic traits in livestock Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/genetic-and-phenotypic-traits-in-livestock/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 30 |
| Journal | Proceedings of the National Academy of Sciences |
| Year | 2024 |
| DOI | 10.1073/pnas.2322291121 |
| Corresponding authors | Xiaolong Liang, Qijiao Duan, Bowen Li, Jianquan Liu, Eviatar Nevo, Kexin Li |
| Institution | Lanzhou University, China |

**Ranking page:** [Topics and Trends in Most Cited Genetic and phenotypic traits in livestock Papers, Class of 2026](https://pri.pepkio.com/top-papers/genetic-and-phenotypic-traits-in-livestock/2026)

**Paper link:** [10.1073/pnas.2322291121](https://doi.org/10.1073/pnas.2322291121)

## Topics

Structural variation · Tibetan sheep · Hu sheep · High-altitude adaptation · Qinghai-Tibet plateau · EPAS1 gene · PAPSS2 · PTPRD · cis-acting effects · Single-cell RNA sequencing · luciferase reporter assay · chromosomal inversion · chromatin architecture · intramuscular adipogenesis · angiogenesis · DNA repair genes · cardiac function genes · tissue-specific gene expression · heart protection genes · circulation-associated genes

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Genetic and phenotypic traits in livestock Papers, Class of 2026. https://pri.pepkio.com/top-papers/genetic-and-phenotypic-traits-in-livestock/2026. Accessed 2026-07-15.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```