# Edible mycelium bioengineered for enhanced nutritional value and sensory appeal using a modular synthetic biology toolkit

*PRI Rank #6 · Topics and Trends in Most Cited Fungal Biology and Applications Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/fungal-biology-and-applications/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 47 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-46314-8 |
| Corresponding authors | Jay D. Keasling |
| Institution | University of California, Berkeley, United States |

**Ranking page:** [Topics and Trends in Most Cited Fungal Biology and Applications Papers, Class of 2026](https://pri.pepkio.com/top-papers/fungal-biology-and-applications/2026)

**Paper link:** [10.1038/s41467-024-46314-8](https://doi.org/10.1038/s41467-024-46314-8)

## Topics

Aspergillus oryzae · filamentous fungi · CRISPR-Cas9 gene integration · modular synthetic biology toolkit · tunable promoters · neutral loci · ergothioneine · heme biosynthesis · Edible fungal biomass · fungal meat alternatives · nutraceutical production · flavor molecule engineering · color pigment engineering · bioengineered food production · fermented foods · Mycoprotein production · imitation meat patties · intracellular metabolite elevation · Edible fungal biomass · sustainable food system

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Fungal Biology and Applications Papers, Class of 2026. https://pri.pepkio.com/top-papers/fungal-biology-and-applications/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```