# A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1

*PRI Rank #18 · Topics and Trends in Most Cited Fungal Biology and Applications Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/fungal-biology-and-applications/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 31 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-48029-2 |
| Corresponding authors | Jarrod R. Fortwendel |
| Institution | St. Jude Children's Research Hospital, United States |

**Ranking page:** [Topics and Trends in Most Cited Fungal Biology and Applications Papers, Class of 2026](https://pri.pepkio.com/top-papers/fungal-biology-and-applications/2026)

**Paper link:** [10.1038/s41467-024-48029-2](https://doi.org/10.1038/s41467-024-48029-2)

## Topics

Azole antifungals · Aspergillus fumigatus · Ergosterol biosynthesis · CYP51 · Sterol 14-demethylase · HMG-CoA reductase · sterol sensing domain · sterol intermediate perturbations · Insulin-Induced Gene orthologs · negative feedback regulation · invasive aspergillosis · antifungal resistance · HMG-CoA reductase mutations · sterol sensing domain mutations · secondary mechanism of action · Pathway downregulation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Fungal Biology and Applications Papers, Class of 2026. https://pri.pepkio.com/top-papers/fungal-biology-and-applications/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```