# <i>Ganoderma lucidum</i> Polysaccharide Supplementation Significantly Activates T-Cell-Mediated Antitumor Immunity and Enhances Anti-PD-1 Immunotherapy Efficacy in Colorectal Cancer

*PRI Rank #15 · Topics and Trends in Most Cited Fungal Biology and Applications Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/fungal-biology-and-applications/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 37 |
| Journal | Journal of Agricultural and Food Chemistry |
| Year | 2024 |
| DOI | 10.1021/acs.jafc.3c08385 |
| Corresponding authors | Zhongguang Luo, Jie Liu, Jian‐Lin Wu |
| Institution | Macau University of Science and Technology, China |

**Ranking page:** [Topics and Trends in Most Cited Fungal Biology and Applications Papers, Class of 2026](https://pri.pepkio.com/top-papers/fungal-biology-and-applications/2026)

**Paper link:** [10.1021/acs.jafc.3c08385](https://doi.org/10.1021/acs.jafc.3c08385)

## Topics

Ganoderma lucidum polysaccharide · Ganoderma lucidum polysaccharides · T-cell-mediated antitumor immunity · anti-PD-1 immunotherapy · Colorectal cancer (CRC) · Colorectal cancer (CRC) · cytotoxic CD8+ T cells · Th1 helper cells · Tregs · microbiota dysbiosis · short-chain fatty acids · kynurenine · tryptophan · Kyn/Trp ratio · immune checkpoint inhibitor · prebiotic · combination immunotherapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Fungal Biology and Applications Papers, Class of 2026. https://pri.pepkio.com/top-papers/fungal-biology-and-applications/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```