# Anti-inflammatory and immunomodulatory properties of polysaccharides in mushrooms

*PRI Rank #14 · Topics and Trends in Most Cited Fungal Biology and Applications Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/fungal-biology-and-applications/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 37 |
| Journal | Current Opinion in Biotechnology |
| Year | 2024 |
| DOI | 10.1016/j.copbio.2024.103076 |
| Corresponding authors | Masashi Mizuno |
| Institution | Osaka Aoyama University, Japan |

**Ranking page:** [Topics and Trends in Most Cited Fungal Biology and Applications Papers, Class of 2026](https://pri.pepkio.com/top-papers/fungal-biology-and-applications/2026)

**Paper link:** [10.1016/j.copbio.2024.103076](https://doi.org/10.1016/j.copbio.2024.103076)

## Topics

Mushroom polysaccharides · Anti-inflammatory activity · Immunomodulation · β-glucan · macrophage activation · cytokine modulation · NK cell activity · T cell proliferation · complement system activation · NF-κB signaling pathway · Toll-like receptors · innate immunity · adaptive immunity · Lentinan · Schizophyllan · Grifolan · Structure-activity relationship · oral bioavailability · therapeutic applications

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Fungal Biology and Applications Papers, Class of 2026. https://pri.pepkio.com/top-papers/fungal-biology-and-applications/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```