# Hallmarks of female reproductive aging in physiologic aging mice

*PRI Rank #7 · Topics and Trends in Most Cited Estrogen and related hormone effects Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/estrogen-and-related-hormone-effects/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 51 |
| Journal | Nature Aging |
| Year | 2024 |
| DOI | 10.1038/s43587-024-00769-y |
| Corresponding authors | Francesca E. Duncan |
| Institution | Buck Institute for Research on Aging, United States |

**Ranking page:** [Topics and Trends in Most Cited Estrogen and related hormone effects Papers, Class of 2026](https://pri.pepkio.com/top-papers/estrogen-and-related-hormone-effects/2026)

**Paper link:** [10.1038/s43587-024-00769-y](https://doi.org/10.1038/s43587-024-00769-y)

## Topics

Female reproductive aging · physiologic aging mice · Female reproductive aging · oocyte quality decline · follicular depletion · Hormonal changes · estrous cycle irregularity · age-related infertility · ovarian reserve · granulosa cell dysfunction · mitochondrial dysfunction in oocytes · DNA damage accumulation · aneuploidy · spindle assembly checkpoint · oxidative stress · inflammatory signaling · extracellular matrix remodeling · vascular changes in ovary · primordial follicle activation · Female reproductive aging

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Estrogen and related hormone effects Papers, Class of 2026. https://pri.pepkio.com/top-papers/estrogen-and-related-hormone-effects/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```