# Spike ripples localize the epileptogenic zone best: an international intracranial study

*PRI Rank #5 · Topics and Trends in Most Cited Epilepsy research and treatment Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epilepsy-research-and-treatment/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 36 |
| Journal | Brain |
| Year | 2024 |
| DOI | 10.1093/brain/awae037 |
| Corresponding authors | Wen Shi, Catherine J. Chu |
| Institution | Massachusetts General Hospital, United States |

**Ranking page:** [Topics and Trends in Most Cited Epilepsy research and treatment Papers, Class of 2026](https://pri.pepkio.com/top-papers/epilepsy-research-and-treatment/2026)

**Paper link:** [10.1093/brain/awae037](https://doi.org/10.1093/brain/awae037)

## Topics

spike ripples · epileptogenic zone localization · Intracranial EEG · automated spike ripple detector · High-frequency oscillations · fast ripples · ripples · Interictal biomarkers · spike-gamma · Interictal epileptiform spikes · Surgical resection · ILAE outcome classification · multicentre intracranial study · depth electrodes · subdural electrodes · Surgical resection · Epilepsy surgery · biomarker validation · seizure freedom prediction · Surgical resection

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epilepsy research and treatment Papers, Class of 2026. https://pri.pepkio.com/top-papers/epilepsy-research-and-treatment/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```