# Risk of Major Congenital Malformations and Exposure to Antiseizure Medication Monotherapy

*PRI Rank #1 · Topics and Trends in Most Cited Epilepsy research and treatment Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epilepsy-research-and-treatment/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 66 |
| Journal | JAMA Neurology |
| Year | 2024 |
| DOI | 10.1001/jamaneurol.2024.0258 |
| Corresponding authors | Dina Battino |
| Institution | Fondazione IRCCS Istituto Neurologico Carlo Besta, Italy |

**Ranking page:** [Topics and Trends in Most Cited Epilepsy research and treatment Papers, Class of 2026](https://pri.pepkio.com/top-papers/epilepsy-research-and-treatment/2026)

**Paper link:** [10.1001/jamaneurol.2024.0258](https://doi.org/10.1001/jamaneurol.2024.0258)

## Topics

antiseizure medication monotherapy · major congenital malformations · women with epilepsy · prenatal ASM exposure · valproate teratogenicity · phenytoin · phenobarbital · carbamazepine · topiramate · lamotrigine · oxcarbazepine · levetiracetam · dose-dependent teratogenic risk · Observational cohort study · EURAP registry · random-effects logistic regression · temporal trends in ASM prescribing · teratogenic outcome ascertainment · blinded malformation assessment · confounder adjustment in pregnancy outcomes

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epilepsy research and treatment Papers, Class of 2026. https://pri.pepkio.com/top-papers/epilepsy-research-and-treatment/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```