# Lactylation‐Driven IGF2BP3‐Mediated Serine Metabolism Reprogramming and RNA m6A—Modification Promotes Lenvatinib Resistance in HCC

*PRI Rank #8 · Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 106 |
| Journal | Advanced Science |
| Year | 2024 |
| DOI | 10.1002/advs.202401399 |
| Corresponding authors | Jianping Zhao, Changzhen Shang, Huifang Liang, Wanguang Zhang |
| Institution | Huazhong University of Science and Technology, China |

**Ranking page:** [Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026](https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026)

**Paper link:** [10.1002/advs.202401399](https://doi.org/10.1002/advs.202401399)

## Topics

lenvatinib resistance · hepatocellular carcinoma · lysine lactylation · IGF2BP3 · PCK2 · NRF2 · serine metabolism reprogramming · N6-methyladenosine (m6A) modification · S-adenosylmethionine (SAM) · glycolysis · lactate accumulation · antioxidant defense system · RNA m6A methylation · lactylated IGF2BP3-PCK2-SAM-m6A loop · 2-Deoxy-D-glucose · siRNA targeting IGF2BP3 · liposome delivery · metabolic adaptation · epigenetic remodeling · molecular-targeted therapy resistance

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```