# Histone lactylation drives CD8+ T cell metabolism and function

*PRI Rank #5 · Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 138 |
| Journal | Nature Immunology |
| Year | 2024 |
| DOI | 10.1038/s41590-024-01985-9 |
| Corresponding authors | Sangeeta Goswami |
| Institution | The University of Texas MD Anderson Cancer Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026](https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026)

**Paper link:** [10.1038/s41590-024-01985-9](https://doi.org/10.1038/s41590-024-01985-9)

## Topics

histone lactylation · CD8+ T cells · T cell metabolism · lactate · Epigenetic modification · glycolysis · Effector T cells · T cell activation · Metabolic reprogramming · Histone modification

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```