# H3K18 Lactylation Potentiates Immune Escape of Non–Small Cell Lung Cancer

*PRI Rank #4 · Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 166 |
| Journal | Cancer Research |
| Year | 2024 |
| DOI | 10.1158/0008-5472.can-23-3513 |
| Corresponding authors | Cai Zhang |
| Institution | The First Affiliated Hospital of Zhengzhou University, China |

**Ranking page:** [Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026](https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026)

**Paper link:** [10.1158/0008-5472.can-23-3513](https://doi.org/10.1158/0008-5472.can-23-3513)

## Topics

H3K18 lactylation · lysine lactylation · non-small cell lung cancer · Immune evasion · CD8+ T-cell cytotoxicity · PD-L1 · POM121 · POM121 · MYC · glycolysis inhibition · 2-Deoxy-D-glucose · oxamate · LDHA · lactate dehydrogenase B · CD274 promoter · anti-PD-1 antibody · tumor microenvironment remodeling · MYC nuclear transport · combination immunotherapy · Metabolic reprogramming

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```