# Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma

*PRI Rank #3 · Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 167 |
| Journal | Molecular Cancer |
| Year | 2024 |
| DOI | 10.1186/s12943-024-02008-9 |
| Corresponding authors | Fei Li, Wenzhe Si, Li Xia |
| Institution | Peking University Third Hospital, China |

**Ranking page:** [Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026](https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026)

**Paper link:** [10.1186/s12943-024-02008-9](https://doi.org/10.1186/s12943-024-02008-9)

## Topics

histone lactylation · H3K18 lactylation · Pancreatic cancer · glycolysis · LDHA · LDHA · P300 · P300 · HDAC2 · TTK protein kinase · BUB1B · mitotic checkpoint regulators · CUT&Tag · LDHA Y239 phosphorylation · LDHA Y239 phosphorylation · positive feedback loop · Metabolic reprogramming · histone writers and erasers · lactate-dependent histone modification · glycolysis-H3K18la-TTK/BUB1B axis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```